免疫檢查點抗體和蛋白
免疫檢查點阻斷抗體可通過增強免疫系統功能來與癌癥作戰，近年來這種癌癥免疫療法正成為治療各類惡性腫瘤的重要方法之一。CTLA-4是第一個用于臨床的免疫檢查點靶點，其抑制劑ipilimumab在2011年批準上市。程序性死亡受體-1（PD-1）與其配體PD-L1，作為治療惡性腫瘤的新靶點也有巨大潛力。今后多靶點聯合用藥將會給癌癥治療帶來更好的療效。
金斯瑞提供多種免疫檢查點相關產品，包括抗體，蛋白和細胞系等，為您的免疫治療研究助一臂之力。更多靶點的產品正在陸續上市。
免疫檢查點抗體的應用
- 人源化抗體藥物早期開發的陽性對照
- 替代抗體（小鼠抗小鼠抗體）
- 抗免疫檢查點抗體藥物抗體（抗獨特型抗體）
訂購信息（宿主：Rabbit）
相關產品
訂購信息（宿主：Mouse）
候選藥物的抗體（Drug candidate antibody）
- 抗體藥物開發的陽性對照
- 制備細胞系
- 研究分析方法
Target
Cat.No.
Product Name
ELISA
FACS
Functional Assay
PD1
?
?
?
?
?
?
PDL1
?
?
?
?
?
?
CTLA-4
?
?
?
?
?
?
TIM3
?
?
?
?
替代抗體 （Surrogate antibody）
- 靶標確認
- 組合療法評估
Target
Cat.No.
Product Name
ELISA
FACS
Functional Assay
CTLA-4
?
?
抗獨特型抗體（Anti-idiotype Antibody）
- 開發生物分析方法 (PK/PD)
- 免疫原性研究
Target
Drug Name
Cat.No
Product Name
Clone ID
Inhibitory,IC50((μg/ml)
Recommend Applications
PD-1
Pembrolizumab (Keytruda)
A01844-40
Anti-Pembrolizumab Antibody mAb, Mouse
1D6E10
Non-inhibitory
Indirect ELISA,Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01845
A01845-40
Anti-Pembrolizumab Antibody [Biotin], mAb, Mouse
10E12C6
0.37
Direct/Inhibitory ELISA,Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01844
A01852-40
MonoRab™ Anti-Pembrolizumab Antibody, mAb, Rabbit
129G11B9
Non-inhibitory
Indirect ELISA,Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01853
A01853-40
MonoRab™ Anti-Pembrolizumab Antibody [BIOTIN], mAb, Rabbit
90G12F8
0.38
Direct/Inhibitory ELISA, Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01852
A01846-40
Anti-Pembrolizumab Antibody, pAb, Rabbit
N/A
Direct ELISAImmunogenicity assay
Nivolumab (Opdivo)
A01847-40
Anti-Nivolumab Antibody, mAb, Mouse
8G6G3D8
Non-inhibitory
Indirect ELISA, Capture antibody for Nivolumab, PK/PD bridging ELISA with A01848-40
A01848-40
Anti-Nivolumab Antibody [Biotin], mAb, Mouse
6G5H2E6
Non-inhibitory
Direct/Indirect ELISA,Detection antibody for Nivolumab, PK/PD bridging ELISA with A01847-40
CTLA-4
Ipilimumab (Yervoy)
A01859-40
Anti-Ipilimumab Antibody, mAb, Mouse
26B6H7D9
Non-inhibitory
Indirect ELISA,Capture antibody for Ipilimumab, PK/PD bridging ELISA with A01858-40
A01858-40
Anti-Ipilimumab Antibody [Biotin], mAb, Mouse
4H6E1D4
Non-inhibitory
Direct/Indirect ELISA,Detection antibody for Ipilimumab, PK/PD bridging ELISA with A01859-40
| Target | Cat.No. | Product Name | ELISA | FACS | Functional Assay |
|---|---|---|---|---|---|
| PD1 | ? |
? |
? |
||
? |
? |
? |
|||
| PDL1 | ? |
? |
? |
||
? |
? |
? |
|||
| CTLA-4 | ? |
? |
? |
||
? |
? |
? |
|||
| TIM3 | ? |
? |
|||
? |
? |
| Target | Cat.No. | Product Name | ELISA | FACS | Functional Assay |
|---|---|---|---|---|---|
| CTLA-4 | ? |
||||
? |
| Target | Drug Name | Cat.No | Product Name | Clone ID | Inhibitory,IC50((μg/ml) | Recommend Applications |
|---|---|---|---|---|---|---|
| PD-1 | Pembrolizumab (Keytruda) | A01844-40 | Anti-Pembrolizumab Antibody mAb, Mouse | 1D6E10 | Non-inhibitory | Indirect ELISA,Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01845 |
| A01845-40 | Anti-Pembrolizumab Antibody [Biotin], mAb, Mouse | 10E12C6 | 0.37 | Direct/Inhibitory ELISA,Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01844 | ||
| A01852-40 | MonoRab™ Anti-Pembrolizumab Antibody, mAb, Rabbit | 129G11B9 | Non-inhibitory | Indirect ELISA,Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01853 | ||
| A01853-40 | MonoRab™ Anti-Pembrolizumab Antibody [BIOTIN], mAb, Rabbit | 90G12F8 | 0.38 | Direct/Inhibitory ELISA, Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01852 | ||
| A01846-40 | Anti-Pembrolizumab Antibody, pAb, Rabbit | N/A | Direct ELISAImmunogenicity assay | |||
| Nivolumab (Opdivo) | A01847-40 | Anti-Nivolumab Antibody, mAb, Mouse | 8G6G3D8 | Non-inhibitory | Indirect ELISA, Capture antibody for Nivolumab, PK/PD bridging ELISA with A01848-40 | |
| A01848-40 | Anti-Nivolumab Antibody [Biotin], mAb, Mouse | 6G5H2E6 | Non-inhibitory | Direct/Indirect ELISA,Detection antibody for Nivolumab, PK/PD bridging ELISA with A01847-40 | ||
| CTLA-4 | Ipilimumab (Yervoy) | A01859-40 | Anti-Ipilimumab Antibody, mAb, Mouse | 26B6H7D9 | Non-inhibitory | Indirect ELISA,Capture antibody for Ipilimumab, PK/PD bridging ELISA with A01858-40 |
| A01858-40 | Anti-Ipilimumab Antibody [Biotin], mAb, Mouse | 4H6E1D4 | Non-inhibitory | Direct/Indirect ELISA,Detection antibody for Ipilimumab, PK/PD bridging ELISA with A01859-40 |
免疫檢查點蛋白的應用
- 調節免疫反應
- 識別結合蛋白
- 發現新藥
- 生產抗體
訂購信息（注：以下靶點的蛋白產品即將上市）
靶點 |
產品貨號 |
|---|---|
| Human PD-1 | Z03370 |
| Human PD-L1 | Z03371 |
| Human PD-L2 | Z03417 |
| Human PVR/CD155 | Z03435 |
| Z03436 | |
| Human SIRPα | Z03420 |
| Z03421 | |
| Human TIGIT | Z03439 |
| Human CTLA4 | Z03373 |
| Human CD19 | Z03407 |
| Human B7-2 | Z03416 |
| Human B7-H2 | Z03414 |
| Z03415 | |
| Human B7-H3 | Z03426 |
| Z03427 | |
| Human CD40 ECD | Z03398 |
| Human OX40 | Z03438 |
| Human TIM3 | Z03392 |
| Human CD137 | Z03382 |
| Human HVEM | Z03224 |
| Human VSIG8-Ig | Z03399 |
| Human CD40L | Z02022 |
| Human CD40L | Z02727 |
| Human VISTA | Z03397 |
| Human 4-1BB L | Z03406 |
| Human CD80 | Z03409 |
| Human LAG3 | Coming soon |
| Mouse OX40 | Z03403 |
| Mouse TIM3 | Z03401 |
